產生惡果;造成重大損失(或傷亡、災難等)
take a heavy toll (on sb / sth)
to have a bad effect on sb / sth; to cause a lot of damage, deaths, suffering, etc.
Illness had taken a heavy toll on her.疾病對她的身體造成極大的損害。
釋義來自《牛津高階英漢雙解詞典》第 9 版