What does “that's for sure” mean?

Said after a statement or as a reply to stress that something is definitely true, or to agree strongly with what was just said.

How is “that's for sure” used?

In Requiem for a Dream (2000), one line is: “Man ain't gonna lay no nickel bag on you, that's for sure.”

The clip at the top of this page is from Requiem for a Dream (2000).

Man ain't gonna lay no nickel bag on you, that's for sure.

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