What does “what's the matter with you” mean?

Used to rebuke someone for acting strangely, rudely, or unreasonably.

How is “what's the matter with you” used?

In Tucker and Dale vs. Evil (2010), one line is: “- What is the matter with you? - Tell me!”

The clip at the top of this page is from Tucker and Dale vs. Evil (2010).

- What is the matter with you? - Tell me!

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