to begin a journey; to make a bomb, etc. explode; to make an alarm start ringing; to start a process or series of events
Oxford40% of films
to begin a journey
And so Barbie and Ken set off
Oxford30% of films
to make a bomb, etc. explode
Oxford15% of films
to make an alarm start ringing
Oh, fuck 'em. They set off the alarm.
Oxford5% of films
to start a process or series of events
Definitions from the Oxford Advanced Learner's Dictionary, 9th edition