What does “no matter what” mean?

used to say that sth is always true, whatever the situation is, or that sb should certainly do sth

How is “no matter what” used?

In Inception (2010), one line is: “And no matter what I do, no matter how hopeless I am...”

The clip at the top of this page is from Inception (2010).

And no matter what I do, no matter how hopeless I am...

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