What does “be out of your mind” mean?

to be unable to think or behave in a normal way; to become crazy

How is “be out of your mind” used?

In Dune: Part Two (2024), one line is: “- You're out of your mind. - He's bluffing.”

The clip at the top of this page is from Dune: Part Two (2024).

- You're out of your mind. - He's bluffing.

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