What does “once and for all” mean?

now and for the last time; finally or completely

How is “once and for all” used?

In The Grand Budapest Hotel (2014), one line is: “and head for the Maltese Riviera, once and for all.”

The clip at the top of this page is from The Grand Budapest Hotel (2014).

and head for the Maltese Riviera, once and for all.

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