产生恶果;造成重大损失(或伤亡、灾难等)
take a heavy toll (on sb / sth)
to have a bad effect on sb / sth; to cause a lot of damage, deaths, suffering, etc.
Illness had taken a heavy toll on her.疾病对她的身体造成极大的损害。
释义来自《牛津高阶英汉双解词典》第 9 版