What does “you can never tell” mean?

you can never be sure, for example because things are not always what they appear to be

How is “you can never tell” used?

In Mona Lisa (1986), one line is: “You can never tell with women, George. They're different.”

The clip at the top of this page is from Mona Lisa (1986).

You can never tell with women, George. They're different.

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